I'm having some fun having my characters swap weapons, with some surprising results.

For example, Canderous' regeneration gives him advantages as a melee-weapon fighter, even though he already has invested in the Heavy Weapons ability.

I've noticed that Carth is really good at using rifle-class weapons, particularly if you give him proficiency in that class of weapon. I am currently experimenting with him using Zalbar's Bowcaster, which is upgradeable and does a lot of damage, plus has bonuses to hit and a sweet Critical Range (17-20).